Adenovirus 2 E1B-55K protein relieves p53-mediated transcriptional repression of the survivin and MAP4 promoters

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• 作者：Punga ; Tanel ; Akusj&auml ; rvi ; Gö ; ran
• 关键词：Adenovirus ; E1B-55K ; Survivin ; Sin3A
• 刊名：FEBS Letters
• 出版年：2003
• 出版时间：September 25, 2003
• 年：2003
• 卷：552
• 期：2-3
• 页码：214-218
• 全文大小：209 K

文摘

It is well established that adenovirus E1B-55K protein functions as an inhibitor of the tumor suppressor protein p53 by binding and inactivating p53 as a transcriptional activator protein. Here we show that the adenovirus 2 E1B-55K protein also blocks p53 as a transcriptional repressor protein of the survivin and the MAP4 promoters. The repression is dependent on the ability of E1B-55K to bind to p53 and is enhanced by coexpression of the adenovirus E4orf6 protein. Overexpression of the transcriptional corepressor protein Sin3A partially relieves the inhibitory effect of E1B-55K, suggesting that E1B-55K blocks p53 functions by interfering with the Sin3 complex.