TNAP stimulates vascular smooth muscle cell trans-differentiation into chondrocytes through calcium deposition and BMP-2 activation: Possible implication in atherosclerotic plaque stability
刊名:Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
出版年:2017
出版时间:March 2017
年:2017
卷:1863
期:3
页码:643-653
全文大小:829 K
卷排序:1863
文摘
TNAP activation in VSMCs appears sufficient to induce calcification. TNAP activation in VSMCs stimulates expression of chondrocyte markers. TNAP inhibition in chondrocytes leads to a loss of multiple differentiation markers. Crystals stimulate expression of BMP-2 in VSMCs. TNAP may stimulate chondrogenesis in VSMCs through crystals and BMP-2.