Prophylactic acetylsalicylic acid attenuates the inflammatory response but fails to protect exercise-induced liver damage in exercised rats

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• 作者：Kuo-Chin Huang^a ; ^{kchsports@mmc.edu.tw" class="auth_mail" title="E-mail the corresponding author} ; Yi-Han Chiu^b ; ^{chiuyiham@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Kuang-Wen Liao^c ; ^{liaonms@mail.nctu.edu.tw" class="auth_mail" title="E-mail the corresponding author} ; Chun-Yen Ke^c ; ^{brant77123@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Chung-Jen Lee^d ; ^{guggilee@msn.com" class="auth_mail" title="E-mail the corresponding author} ; Yann-Fen C. Chao^e ; ^{yfchaomk@mmc.edu.tw" class="auth_mail" title="E-mail the corresponding author} ; Ru-Ping Lee^f ; ^{fish@gms.tcu.edu.tw" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Nonsteroidal antiinflammatory drug ; Aspirin ; Exhaustion exercise ; Liver injury
• 刊名：European Journal of Pharmacology
• 出版年：2016
• 出版时间：5 September 2016
• 年：2016
• 卷：786
• 期：Complete
• 页码：204-211
• 全文大小：2697 K

文摘

This study evaluated the effects of acetylsalicylic acid (ASA) on exercise-induced inflammatory response, muscle damage, and liver injury in rats. Wistar-Kyoto (WKY) rats were divided into six groups: control (C), exercise (E), C+20 mg ASA, E+20 mg ASA, C+100 mg/kg ASA, and E+100 mg ASA groups. ASA or a vehicle was orally administered through gavage 1 h before a treadmill test. Upon trial completion, blood was drawn at 1, 12, and 24 h for biochemical analysis, and livers were excised at 24 h for a histological assessment. Our results revealed that 100 mg/kg ASA significantly reduced interleukin (IL)-6 and tumor necrosis factor (TNF)-α levels in the E groups; however, the IL-10 level was considerably increased. Moreover, aspartate aminotransferase (AST), alanine aminotransferase (ALT) levels and histological hepatic damage increased significantly in the E+100 mg ASA group compared with the corresponding changes in the E group. These results suggest that the prophylactic administration of particularly high-dose ASA alleviates exercise-induced inflammatory response but exacerbates liver injury.