Mutation in lamin A/C sensitizes the myocardium to exercise-induced mechanical stress but has no effect on skeletal muscles in mouse
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- 作者：Marie-Elodie Cattina ; 1 ; mcattin@ottawaheart.ca" class="auth_mail" title="E-mail the corresponding author ; Arnaud Ferrya ; b ; Alban Vignauda ; 2 ; Nathalie Mougenotc ; Adeline Jacquetc ; Karim Wahbia ; b ; d ; Anne T. Bertranda ; Gisè ; le Bonnea
- 关键词：A-type lamin ; L-CMD ; Dilated cardiomyopathy ; Mechanical stress ; Chronic exercise
- 刊名：Neuromuscular Disorders
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：26
- 期：8
- 页码：490-499
- 全文大小：2200 K
文摘
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The impact of exercise on heart and muscles of LmnadelK32/+ mice was investigated.
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Strenuous chronic exercise led to earlier onset of the cardiomyopathy in LmnadelK32/+ mice.
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Skeletal muscle structure and function was not impacted by exercise-induced stress.