Influence of Recanalization and Time of Cerebral Ischemia on聽Tissue Outcome after Endovascular Stroke Treatment on聽Computed Tomography Perfusion

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• 作者：Anselm Angermaier ; MD ; MSc^&lowast ; ; Alexander V. Khaw ; MD^&dagger ; ; ^&lowast ; ; Michael Kirsch ; MD^&Dagger ; ; Christof Kessler ; MD ; PhD^&lowast ; ; Soenke Langner ; MD ; PhD^&Dagger ; ; ^{soenke.langner@uni-greifswald.de" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Ischemic stroke ; intra-arterial thrombolysis ; endovascular intervention ; perfusion CT ; ASPECTS
• 刊名：Journal of Stroke and Cerebrovascular Diseases
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：24
• 期：10
• 页码：2306-2312
• 全文大小：568 K

文摘

The Alberta Stroke Program Early Computed Tomography Score (ASPECTS) has been proposed as a straightforward alternative to the less reliable visual estimation of tissue at risk. We evaluated the association between admission ASPECTS on computed tomography perfusion (CTP) parameter maps and final infarct ASPECTS in patients with acute ischemic stroke who were treated by endovascular therapy (eT) and compared the results with thrombolysis candidates treated conservatively.

Methods

eT was performed in 26 consecutive ischemic stroke patients within 6 hours of symptom onset. The control group was matched for age and admission National Institutes of Health Stroke Scale having the same admission imaging protocol and a transcranial Doppler sonography within 24 hours. ASPECTS determined from CTP maps of cerebral blood flow (CBF), cerebral blood volume (CBV), and time to peak (TTP) were compared with final infarct ASPECTS on day 5 noncontrast CT.

Results

Recanalization rate was 73% in treatment and 50% in control group. ASPECTS for all CTP parameters were significantly lower than ASPECTS-CT in both groups (P < .005). In the treatment group, this applied to patients with successful recanalization. Only controls without recanalization showed a strong correlation between ASPECTS-CTP parameters and ASPECTS-CT (CBV: P = .005; CBF and TTP: P = .028). Patients with early recanalization (≤4 hours) had greater differences between ASPECTS-CTP and ASPECTS-CT than patients with late recanalization (>4 hours; CBF: P = .056; CBV: P = .095; TTP: P = .048).

Conclusions

The initial ASPECTS-CTP lesion was significantly larger than the final infarct determined by ASPECTS in case of recanalization. Initial perfusion lesion, including CBV, is reversible in case of reperfusion, especially in early reperfusion.