Inhibition of multixenobiotic resistance transporters (MXR) by silver nanoparticles and ions in vitro and in Daphnia magna
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- 作者：Anastasia Georgantzopouloua ; 1 ; Sé ; bastien Cambiera ; Tommaso Serchia ; Marcin Kruszewskib ; c ; Yekkuni L. Balachandrand ; Patrick Grysane ; Jean-Nicolas Audinote ; Johanna Ziebela ; Cé ; dric Guignarda ; Arno C. Gutleba ; arno.gutleb@list.lu" class="auth_mail" title="E-mail the corresponding author ; AlberTinka J. Murkf ; g ; tinka.murk@wur.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cellular efflux transporters ; MDCKII-MDR1 ; MDR/MXR ; P-glycoprotein ; Silver nanoparticles ; Daphnia magna
- 刊名：Science of the Total Environment
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：569-570
- 期：Complete
- 页码：681-689
- 全文大小：911 K
文摘
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The NP surface properties and size influence the extent of MXR inhibition.
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Both released Ag ions and Ag NPs themselves contribute to the inhibition.
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MXR modulation should be taken into account when assessing NP toxicity.
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Daphnia magna is suitable for in vivo MXR-NP modulation studies.
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Further understanding of NPs/environmental contaminants mixture effects needed