In聽vitro immunotoxicological effects of heavy metals on European sea bass (Dicentrarchus labrax L.) head-kidney leucocytes
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- 作者：Patricia Morcillo ; Hé ; ctor Cordero ; José ; Meseguer ; M. Á ; ngeles Esteban ; Alberto Cuesta ; alcuesta@um.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：Heavy metals ; Apoptosis ; Oxidative stress ; ROS ; Phagocytosis ; European sea bass
- 刊名：Fish & Shellfish Immunology
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：47
- 期：1
- 页码：245-254
- 全文大小：577 K
文摘
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Heavy metals induced ROS production in European sea bass HK leucocytes.
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Cd and MeHg promoted apoptosis or necrosis cell death in sea bass HK leucocytes.
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Cd, Hg and As decreased while Pb increased phagocyte immune functions.
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Heavy metals slightly altered the transcription of immune-related genes.
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Freshly isolated fish leucocytes are a very good tool for immunotoxicological determinations.