文摘
Subarachnoid hemorrhage activates cerebral innate immunity by Mincle/Syk pathway. Albumin can abolish immune responses by directly binding microglial Mincle receptor after subarachnoid hemorrhage. Neuronal necroptosis product, SAP130, launches the stimulation of Mincle on microglial cells. Albumin supplementation can deactivate SAP130-induced microglial motivation.