Cobalt(II) complexes of sparfloxacin: Characterization, structure, antimicrobial activity and interaction with DNA and albumins
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- 作者：Eleftherios Kourisa ; Stavros Kalogiannisb ; Franc Perdihc ; Iztok Turelc ; George Psomasa ; gepsomas@chem.auth.gr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cobalt complexes ; Sparfloxacin ; Interaction with DNA ; Interaction with albumins ; Antimicrobial activity
- 刊名：Journal of Inorganic Biochemistry
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：163
- 期：Complete
- 页码：18-27
- 全文大小：963 K
文摘
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Four cobalt(II) complexes with sparfloxacin as ligand were characterized.
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The crystals structures of two mixed-ligand complexes were determined.
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The complexes show noteworthy antimicrobial activity.
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The complexes can bind to human or bovine serum albumins.
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Intercalation is the most possible binding mode of the complexes to calf-thymus DNA.