Reaction of benzyl alcohols, isatoic anhydride, and primary amines mediated by I2/K2CO3 in water: a new and green approach for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones
文摘
An efficient synthesis of 2,3-dihydroquinazolin-4(1H)-ones proceeding via a three-component reaction between benzyl alcohols, isatoic anhydride, and primary amines in the presence of iodine and potassium carbonate is reported. This protocol allows the straightforward preparation of the titled products using readily available benzyl alcohols instead of unstable aldehydes under mild oxidative conditions.