Reaction of benzyl alcohols, isatoic anhydride, and primary amines mediated by I₂/K₂CO₃ in water: a new and green approach for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones

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• 作者：Seyedeh Bahareh Azimi ; Javad Azizian ; ^{j.azizian13@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Benzyl alcohols ; Iodine ; Oxidation ; 2 ; 3-Dihydroquinazolin-4(1H)-ones (DHQZs) ; Green chemistry
• 刊名：Tetrahedron Letters
• 出版年：2016
• 出版时间：13 January 2016
• 年：2016
• 卷：57
• 期：2
• 页码：181-184
• 全文大小：3028 K

文摘

An efficient synthesis of 2,3-dihydroquinazolin-4(1H)-ones proceeding via a three-component reaction between benzyl alcohols, isatoic anhydride, and primary amines in the presence of iodine and potassium carbonate is reported. This protocol allows the straightforward preparation of the titled products using readily available benzyl alcohols instead of unstable aldehydes under mild oxidative conditions.