- 作者：Rafael Deminice ; Helena S. Vassimon ; Alcyone A. Machado ; Francisco J.A. de Paula ; Jacqueline P. Monteiro ; Alceu A. Jordao
- 关键词：Homocysteine ; Sulfur-containing amino acids ; Lipodystrophy ; HIV
- 刊名：Nutrition
- 出版年：2013
- 出版时间：November-December, 2013
- 年：2013
- 卷：29
- 期：11-12
- 页码：1326-1330
- 全文大小：278 K
Objective
Lipodystrophy syndrome is an unexpected clinical manifestation in patients infected with HIV and might be a clinical marker of increased risk for cardiovascular diseases (CVDs). Because hyperhomocysteinemia has been associated with CVD, the goal of the present study was to investigate homocysteine (Hcy) levels and their association with the factors of lipodystrophy syndrome in men with HIV.Methods
Hcy metabolism-related molecules were determined in 13 men infected with HIV with lipodystrophy (HIV+LIP), 10 men with HIV without lipodystrophy (HIV), and 10 healthy controls (C).
Results
Significant (P < 0.05) increased Hcy plasma levels were found in HIV (20.5 % ) and in HIV+LIP (35.2 % ) compared with the control group. Plasma levels of vitamin B12 (HIV, 26.5 % ; HIV+LIP, 28.8 % ) and folate (HIV, 39.1 % and HIV+LIP, 49.4 % ) were significantly (P < 0.05) lower in the two groups of HIV patients compared with control. HIV+LIP men presented raised plasma total sulfur-containing amino acids (20.1 % ) and lower total plasma thiol (11.3 % ) than controls. The same was not observed in the HIV group. Spearman's correlation test revealed significant (P < 0.05) association between plasma Hcy and duration of highly active antiretroviral therapy (HAART) and plasma insulin, as well as plasma adiponectin levels.
Conclusion
Our results demonstrated that HIV+LIP men were more susceptible to disturbances in Hcy metabolism compared with men infected with HIV without lipodystrophy characteristics. Duration of HAART treatment, elevated plasma insulin, and low levels of adiponectin seem to be relevant for the appearance of these Hcy metabolic disorders.