3D surface imaging for monitoring intrafraction motion in frameless stereotactic body radiotherapy of lung cancer

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• 作者：Tanja Alderliesten ; Jan-Jakob Sonke ; Anja Betgen ; Corine van Vliet-Vroegindeweij ; Peter Remeijer ; ^{p.remeijer@nki.nl}
• 关键词：Lung cancer ; Stereotactic body radiotherapy (SBRT) ; Image-guided radiotherapy (IGRT) ; Surface imaging ; Intrafraction motion
• 刊名：Radiotherapy and Oncology
• 出版年：2012
• 出版时间：November, 2012
• 年：2012
• 卷：105
• 期：2
• 页码：155-160
• 全文大小：276 K

文摘

Purpose

To investigate the accuracy of surface imaging for monitoring intrafraction motion purposes in frameless stereotactic body radiotherapy (SBRT) of lung cancer by comparison with cone-beam computed tomography (CBCT).

Materials and methods

Thirty-six patients (18 males, 18 females) were included. During each fraction, three CBCT scans were acquired; CBCT1: before treatment, CBCT2: after correction for tumor misalignment, and CBCT3: after treatment. Intrafraction motion was derived by registering CBCT2 and CBCT3 to the mid-ventilation planning CT scan. Surfaces were captured concurrently with CBCT acquisitions. Retrospectively, for each set of surfaces, an average surface was created: Surface1, Surface2, and Surface3. Subsequently, Surface3 was registered to Surface2 to assess intrafraction motion. For the differences between CBCT- and surface-imaging-derived 3D intrafraction motions, group mean, systematic error, random error and limits of agreement (LOA) were calculated.

Results

Group mean, systematic and random errors were smaller for females than for males: 0.4 vs. 1.3, 1.3 vs. 3.1, and 1.7 vs. 3.3 mm respectively. For female patients deviations between CBCT-tumor- and 3D-surface-imaging-derived intrafraction motions were between ?3.3 and 4.3 mm (95 % LOA). For male patients these were substantially larger: ?5.9-9.5 mm.

Conclusion

Surface imaging is a promising technology for monitoring intrafraction motion purposes in SBRT for female patients.