Ethanol and acetaldehyde differentially alter extracellular dopamine and serotonin in Aldh2-knockout mouse dorsal striatum: A reverse microdialysis study
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- 作者：Mostofa Jamala ; jamaldr68@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; jamal@kms.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Kiyoshi Amenoa ; Takanori Mikib ; Naoko Tanakaa ; Asuka Itoa ; Junichiro Onoc ; Ayaka Takakuraa ; Mitsuru Kumihashia ; Hiroshi Kinoshitaa
- 关键词：Ethanol ; Acetaldehyde ; Dopamine ; Serotonin ; Reverse microdialysis ; Aldh2-KO mice
- 刊名：Neurotoxicology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：52
- 期：Complete
- 页码：204-209
- 全文大小：481 K
文摘
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Perfusion with 500 mM EtOH in the dorsal striatum produced a profound increase in the levels of DA in both Aldh2-KO and WT mice.
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In contrast, perfusion with 200 and 500 μM AcH decreased both DA and 5-HT levels in Aldh2-KO mice, but not in WT mice.
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There were no genotype effects on the basal levels of DA and 5-HT.