Generation of disease-specific autopsy-confirmed iPSCs lines from postmortem isolated Peripheral Blood Mononuclear Cells

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• 作者：Kinsley Belle^a ; Francelethia S. Shabazz^b ; Karen Nuytemans^b ; David A. Davis^c ; Aleena Ali^b ; Juan L. Young^a ; ^b ; William K. Scott^a ; ^b ; Deborah C. Mash^c ; ^d ; Jeffrey M. Vance^a ; ^b ; Derek M. Dykxhoorn^a ; ^b ; ^{DDykxhoorn@med.miami.edu}
• 关键词：iPSCs ; Postmortem ; Autopsy ; PBMCs ; Neurodegeneration ; Disease modeling ; Parkinson disease ; Neuropathological confirmation
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：637
• 期：Complete
• 页码：201-206
• 全文大小：1367 K
• 卷排序：637

文摘

IPSC can be derived rapidly from patient samples retrieved after death. Postmortem blood drawn within 20 h after death can serve as reprogramming material. Autopsy confirmed patient samples are the gold standard for modeling heterogeneous and idiopathic disease.