Regulation of the Immune Response to 伪-Gal and Vector-borne Diseases

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• 作者：Alejandro Cabezas-Cruz¹ ; Lourdes Mateos-Herná ; ndez² ; Magdiel Pé ; rez-Cruz¹ ; James J. Valdé ; s³ ; Isabel G. Ferná ; ndez de Mera² ; Margarita Villar² ; José ; de la Fuente² ; ⁴ ; ^{jose_delafuente@yahoo.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：alpha-gal ; vector-borne diseases ; tick ; vaccine ; malaria
• 刊名：Trends in Parasitology
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：31
• 期：10
• 页码：470-476
• 全文大小：1702 K

文摘

Vector-borne diseases (VBD) challenge our understanding of emerging diseases. Recently, arthropod vectors have been involved in emerging anaphylactic diseases. In particular, the immunoglobulin E (IgE) antibody response to the carbohydrate Gal伪1-3Gal尾1-(3)4GlcNAc-R (伪-gal) following a tick bite was associated with allergies to red meat, cetuximab, and gelatin. By contrast, an anti-伪-gal IgM antibody response was shown to protect against mosquito-borne malaria. Herein, we highlight the interplay between the gut microbiota, vectors, transmitted pathogens, and the regulation of the immune response as a model to understand the protective or allergic effect of 伪-gal. Establishing the source of 伪-gal in arthropod vectors and the immune response to vector bites and transmitted pathogens will be essential for diagnosing, treating, and ultimately preventing these emerging anaphylactic and other vector-borne diseases.