Synthesis of CF3-bearing pyrrolidines by hydrogenation of trifluoroacetylated pyrrole derivatives
详细信息 查看全文
- 作者：Radomyr V. Smaliy ; radomyrs@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Aleksandra A. Chaykovskaya ; Nataliya A. Shtil ; Sergey A. Yurchenko ; Aleksandr A. Yurchenko ; Aleksandr I. Lakhtadyr ; Alina O. Gorlova ; Aleksandr N. Kostyuk
- 关键词：Hydrogenation ; Pyrrole ; Palladium ; Amines ; Fluorine
- 刊名：Journal of Fluorine Chemistry
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：180
- 期：Complete
- 页码：257-264
- 全文大小：976 K
文摘
- •
An approach to CF3-bearing pyrrolidines was developed.
- •
The CF3-bearing pyrroles were found to be easily hydrogenated by Pd/C promoted by HCl.
- •
In some cases trifluoroacetyl groups were reduced into trifluoroethyl ones.
- •
Wide scope of substrates was studied including stereochemistry.