Evaluation of prenatal diagnosis of cleft lip/palate by foetal ultrasonographic examination

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• 作者：Stoll ; Claude ; Dott ; Bé ; atrice ; Alembik ; Yves ; Roth ; Marie-Paule
• 关键词：congenital anomalies ; congenital malformations ; prenatal screening ; foetal scan ; oral clefts
• 刊名：Annales de Genetique
• 出版年：1998
• 出版时间：January, 1998
• 年：1998
• 卷：43
• 期：1
• 页码：11-14
• 全文大小：44.3 K

文摘

Ultrasound scans in the midtrimester of pregnancy are now a routine part of antenatal care in many countries. This type of screening procedure can detect serious foetal anomalies. Thanks to our registry of congenital anomalies a study was undertaken. The objective of the study was to evaluate prenatal detection of cleft lip (palate)(CL/P) by routine ultrasonographic examination of the foetus in 265 679 consecutive pregnancies from 1979 to 1998. The percentage of prenatal detection of CL/P was low. For isolated malformation (foetuses with only CL/P) the detection rate was low: 17.8 % ; however, this detection rate increased from 5.3 % during the period 1979–1988 to 26.5 % during the period 1989–1998, for foetuses with associated malformations (foetuses with CL/P and one or more additional major malformations) these detection rates were 34.6, 13.3 and 50.0 % , respectively. In foetuses with associated malformations with CL/P this detection rate was higher for chromosomal abnormalities with CL/P and for non-syndromic, non-chromosomal multiply malformed children with CL/P than for non-chromosomal recognized syndromes with CL/P.