Thioesterase superfamily member 1 suppresses cold thermogenesis by limiting the oxidation of lipid droplet-derived fatty acids in brown adipose tissue
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- 作者：Kosuke Okada1 ; Katherine B. LeClair1 ; Yongzhao Zhang1 ; 4 ; Yingxia Li1 ; Cafer Ozdemir1 ; Tibor I. Krisko1 ; Susan J. Hagen2 ; Rebecca A. Betensky3 ; Alexander S. Banks1 ; David E. Cohen1 ; dcohen@partners.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Energy expenditure ; Fatty acyl-CoA ; Acyl-CoA thioesterase ; Mitochondria ; Obesity
- 刊名：Molecular Metabolism
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：5
- 期：5
- 页码：340-351
- 全文大小：1426 K
文摘
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Them1 is a fatty acyl-CoA thioesterase that is highly expressed in brown adipose tissue.
Them1 expression is strongly upregulated by cold ambient temperatures.
Mice lacking Them1 exhibit increased cold thermogenesis.
Them1 limits the mitochondrial oxidation of lipid-droplet derived fatty acids.