Multiple gene and transcript variants encoding trout C-polysaccharide binding proteins are differentially but strongly induced after infection with Aeromonas salmonicida

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• 作者：Judith M. Kö ; bis^a ; ¹ ; Henrike Rebl^b ; ¹ ; Tom Goldammer^a ; Alexander Rebl^a ; ^{rebl@fbn-dummerstorf.de}
• 关键词：Acute phase ; Complement component ; Innate immunity ; Pentraxin ; TCBP ; Teleost
• 刊名：Fish & Shellfish Immunology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：60
• 期：Complete
• 页码：509-519
• 全文大小：2374 K
• 卷排序：60

文摘

We characterise the full-length sequences of TCBP1 and -2 from rainbow trout. The five different TCBP1 transcripts are generated through different splicing strategies. Evolutionary analyses separate TCPB1 and -2 based on distinctive protein motifs. TCBP1 variants increased several hundredfolds in liver after Aeromonas salmonicida infection. Reporter gene assays indicate that TCBP1 induces a level of active NF-κB in vitro.