Evaluation of alumina toughened zirconia implants with a sintered, moderately rough surface: An experiment in the rat

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• 作者：Ralf J. Kohal^a ; Maria Bä ; chle^a ; Alexander Renz^b ; Frank Butz^a ; ^{frank.butz@uniklinik-freiburg.de" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Dental implants ; Alumina toughened zirconia ; Surface topography ; Histomorphometry ; Push-in test ; Cell-culture study
• 刊名：Dental Materials
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：32
• 期：1
• 页码：65-72
• 全文大小：2520 K

文摘

Alumina toughened zirconia (ATZ) is more fracture resistant than unmodified zirconia and has been shown to be a viable substrate for the growth of osteoblasts. In this study, we examined the histological and biomechanical behavior of moderately roughened ATZ implants in rat femoral bone.

Methods

Miniature implants made of ATZ with pore-building polymers sintered onto the surface and electrochemically anodized titanium (TiUnite^®) were placed into the femurs of Sprague-Dawley rats. Implant surface topography was analyzed by 3D laserscan measurements and scanning electron microscopy (SEM). After a healing period of 14 and 28 days, respectively, histologic and biomechanical testing was performed.

Results

Under the SEM, the TiUnite^® surface could be clearly distinguished from the ATZ surface, but 3D laserscan measurements indicated a moderately rough surface topography for both, TiUnite^® (S_a = 1.31 μm) and ATZ (S_a = 1.51 μm). The mean mineralized bone-to-implant contact showed the highest values after 14 and 28 days for TiUnite^® (58%/75%) as compared to ATZ (24%/41%). The push-in values after a healing period of 14 and 28 days, respectively, increased from 20 N to 39 N for TiUnite^® and from 10 N to 25 N for ATZ.

Significance

Our findings suggest that the moderately roughened ATZ implant surface is well accepted by rat bone tissue. However, compared to titanium, the osseointegration-process of ATZ seems to proceed more slowly in that early phase of implant integration.