Hypovitaminosis D upscales B-cell immunoreactivity in multiple sclerosis
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- 作者：Jü ; rgen Haas ; Alexander Schwarz ; Mirjam Korporal-Kuhnke ; Simon Faller ; Sven Jarius ; Brigitte Wildemann ; brigitte.wildemann@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Multiple sclerosis ; Vitamin D ; Hypovitaminosis D ; B lymphocytes ; B-cell immunoreactivity ; Cerebrospinal fluid
- 刊名：Journal of Neuroimmunology
- 出版年：2016
- 出版时间：15 May 2016
- 年：2016
- 卷：294
- 期：Complete
- 页码：18-26
- 全文大小：935 K
文摘
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B cells from MS patients with hypovitaminosis D exhibit enhanced immune responses ex vivo.
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Hypovitaminosis D coincides with low vitamin D levels and increased frequencies of mature B-cell subtypes in the cerebrospinal fluid.
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Vitamin D-supplementation attenuates B-cell immunoreactivities.