Application of cyclic ketones in MCR: Ugi/amide coupling based synthesis of fused tetrazolo[1,5-a][1,4]benzodiazepines

详细信息    查看全文

• 作者：Swapnil G. Yerande^a ; ^{swapnil_yerande@hikal.com" class="auth_mail} ; Kiran M. Newase^b ; Bhawani Singh^c ; André ; Boltjes^d ; Alexander Dö ; mling^d
• 关键词：Cyclic ketone ; Ugi multi component reaction ; Ugi/amide coupling ; Fused tetrazole-ketopiperazine
• 刊名：Tetrahedron Letters
• 出版年：21 May 2014
• 年：2014
• 卷：55
• 期：21
• 页码：3263-3266
• 全文大小：525 K

文摘

Azido-Ugi reaction involving cyclic ketone, primary amine, isonitrile, and azide afforded substituted tetrazole derivatives 5. These intermediates were hydrolyzed to corresponding acid derivatives. EDAC/HOBt mediated amide bond formation of 5 gave fused tetrazolo[1,5-a][1,4]benzodiazepine 6 in high yield and good diversity.