Brachial Artery Flow-mediated Dilation in Patients with Tako-Tsubo Cardiomyopathy

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• 作者：Elena Vasilieva MD ; PhD  ; ;   ; ^{vasilievahelena@gmail.com} ; Inna Vorobyeva MD ; Anna Lebedeva ; Irina Urazovskaya MD ; PhD ; Anna Kalinskaya MD ; Dmitriy Skrypnik MD ; PhD ; Alexander Shpektor MD ; PhD
• 关键词：Acute myocardial infarction with ST elevation ; Brachial artery flow-mediated dilation test ; Endothelial dysfunction ; Tako-Tsubo cardiomyopathy
• 刊名：The American Journal of Medicine
• 出版年：2011
• 出版时间：December 2011
• 年：2011
• 卷：124
• 期：12
• 页码：1176-1179
• 全文大小：247 K

文摘

Background

Tako-Tsubo cardiomyopathy (TTC) is a heart syndrome associated with transient myocardial contractile dysfunction. The pathogenesis of TTC remains unclear. The purpose of this study was to investigate brachial artery flow-mediated dilation (FMD) in patients with TTC.

Methods

The results of FMD tests of 4 women with TTC were compared with the results from 18 women with ST-elevation acute myocardial infarction (STEMI) and from 26 healthy female volunteers. FMD tests in all patients were performed within 24 hours of admission and again at 1-3 weeks as a follow-up.

Results

The FMD levels were significantly lower at the acute phase in patients with TTC than in patients with STEMI and in healthy volunteers (P <.01). After 1-3 weeks, the FMD test results of patients with TTC had greatly increased, and no significant differences were found between these results and the results from patients with STEMI (P >.05). Also, there were no significant differences in the FMD test results between the group of patients with TTC and the group of healthy volunteers (P >.05).

Conclusions

There is a pronounced and reversible endothelial dysfunction in patients with TTC, which can impair myocardial perfusion.