A novel role for small molecule glycomimetics in the protection against lipid-induced endothelial dysfunction: Involvement of Akt/eNOS and Nrf2/ARE signaling

详细信息    查看全文

• 作者：Ayman M. Mahmoud^a ; ^c ; Fiona L. Wilkinson^a ; Alan M. Jones^b ; James A. Wilkinson^d ; Miguel Romero^e ; Juan Duarte^e ; M. Yvonne Alexander^a ; ^{y.alexander@mmu.ac.uk}
• 关键词：Small molecule drug discovery ; Glycomimetics ; Heparan sulfate ; Endothelial dysfunction ; Oxidative stress
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1861
• 期：1
• 页码：3311-3322
• 全文大小：1860 K
• 卷排序：1861

文摘

Small molecule glycomimetics protect against endothelial dysfunction. Glycomimetics up-regulate Akt/eNOS signaling and restore nitric oxide bioavailability. Glycomimetics reduce oxidative stress via activation of Nrf2/ARE signaling. Glycomimetics improve endothelium-dependent relaxation and decrease ROS production and NADPH oxidase activity.