‘Comparison of extremes’ approach provides evidence against the modifying role of NAT2 polymorphism in lung cancer susceptibility

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• 作者：Belogubova ; Evgeniya V. ; Kuligina ; Ekatherina Sh. ; Togo ; Alexandr V. ; Karpova ; Maria B. ; et. al.
• 关键词：NAT2 ; Acetylators ; Polymorphism ; Genotype ; Lung cancer ; Predisposition ; Elderly
• 刊名：Cancer Letters
• 出版年：2005
• 出版时间：April 28, 2005
• 年：2005
• 卷：221
• 期：2
• 页码：177-183
• 全文大小：99.4 K

文摘

NAT2 (arylamine N-acetyltransferase 2) polymorphism, being a key determinant of individual variations in acetylation capacity, is suspected to modify the risk of carcinogen-related malignancies. As tobacco smoke and other inhaled hazards contain a variety of NAT2 substrates, the relationship between NAT2 phenotype and lung cancer (LC) risk has been a subject of intensive research, however different case–control studies produced controversial data. In the present report, we employed a novel ‘comparison of extremes’ approach, i.e. we compared the distribution of NAT2 genotypes in lung cancer patients (LC, n