GSTM1 genotypes in elderly tumour-free smokers and non-smokers
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- 作者：Belogubova ; Evgeniya V. ; Togo ; Alexandr V. ; Kondratieva ; Tatiana V. ; Lemehov ; Vladimir G. ; et. al.
- 关键词：GSTM1 ; Lung cancer ; Polymorphism ; Cancer predisposition ; Elderly ; ED ; elderly donors ; HD ; healthy donors ; LC ; lung cancer ; OR ; odds ratio
- 刊名：Lung Cancer
- 出版年：2000
- 出版时间：September 1, 2000
- 年：2000
- 卷：29
- 期：3
- 页码：189-195
- 全文大小：80.5 K
文摘
Cancer is known to be an extremely common disease, with the life-time risks reaching close to 0.5 for men and to 0.4 for women. Hence those individuals, who succeeded to achieve a reasonably old age without a history of malignancy, represent a distinct group of interest, which apparently can be defined as ‘tumour-tolerant’. Focus on the genetic features of these subjects may significantly facilitate the research of cancer-predisposing polymorphisms: first, a fundamental understanding of molecular mechanisms conferring the phenomena of cancer resistance appears to be outstandingly important; second, it is promising to involve non-affected geriatric cohorts in the molecular epidemiological studies as a tumour-free control of especial value. Here we analysed the GSTM1 genotype frequencies in the individuals with seemingly different degrees of resistance or susceptibility to neoplasms, such as elderly tumour-free smokers and non-smokers (≥75-years-old), healthy middle-aged donors, and lung cancer patients. The proportion of GSTM1-deficient individuals gradually increased from elderly controls (70/157; 45 % ) to middle-aged ones (77/140; 55 % ) to lung cancer sufferers (34/58; 59 % ), showing the minimal estimates in elderly non-affected smokers (35/81; 43 % ) and the maximal ones in the affected non-smokers (7/7, 100 % ). These data have led to the two groups of conclusions. First, the broad protective role of GSTM1 has been confirmed in this report. In particular, GSTM1-deficiency appeared to reduce the chances of entering an elderly age without a history of malignancy (OR=0.66 (0.42–1.04); P