Hepatic stimulator substance administration affects cadmium-induced hepatotoxicity in the rat

详细信息    查看全文

• 作者：Margeli ; Alexandra P. ; Theocharis ; Stamatios E. ; Spiliopoulou ; Chara ; Horti ; Maria ; Koutselinis ; Antonios
• 关键词：Hepatic stimulator substance ; Cadmium ; Liver ; Toxicity
• 刊名：International Hepatology Communications
• 出版年：1996
• 出版时间：June, 1996
• 年：1996
• 卷：5
• 期：2
• 页码：128-134
• 全文大小：337 K

文摘

The effect of hepatic stimulator substance (HSS) administration on cadmium (Cd) induced hepatotoxicity was studied in the rat. HSS was extracted from the liver of weanling rats (Hepatology 1988; 7: 100-106). Rats were injected with 2.5 mg CdCl₂/kg body weight to induce acute liver injury, evaluated 24 h later. Serum enzyme activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and histological parameters were used for the estimation of Cd-induced hepatotoxicity. HSS, at doses of 10, 20 and 40 mg protein/kg body weight, injected 10 h after Cd administration, caused dose-dependent decrease of hepatic injury. HSS suppressed the elevation of AST and ALT induced by Cd, in a dose-dependent manner. Liver histological changes indicated that HSS reduced the severity of hepatic lesion induced by Cd administration and reversed Cd-induced hepatotoxicity. In conclusion, our results suggest that HSS administration protects the liver against Cd-induced injury.