Faster initiation in the Friedel-Crafts reaction of benzyl fluorides using trifluoroacetic acid as activator
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- 作者：Ré ; my Hemelaere ; Pier Alexandre Champagne ; Justine Desroches ; Jean-Franç ; ois Paquin ; jean-francois.paquin@chm.ulaval.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：C-F bond activation ; Friedel-Crafts alkylation ; Benzyl fluorides ; Hydrogen-bonding
- 刊名：Journal of Fluorine Chemistry
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：190
- 期：Complete
- 页码：1-6
- 全文大小：795 K
文摘
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The addition of trifluoroacetic acid drastically reduces the induction period.
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Lower reaction temperature is enabled.
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Milder conditions for benzylic fluorides bearing an electron-withdrawing group.