• 作者：Alfonso Alcalde Vargas ; ^{alfonavsc@hotmail.com} ; Jos&#233 ; Manuel Herrera Justiniano ; Eduardo Leo Carnerero ; Claudio Trigo Salado ; Ignacio Guti&#233 ; rrez Domingo ; Jos&#233 ; Luis Má ; rquez Galá ; n
• 关键词：Enfermedad de Crohn ; Hemorragia digestiva baja ; Fá ; rmacos bioló ; gicos
• 刊名：Gastroenterolog¨ªa y Hepatolog¨ªa
• 出版年：2011
• 出版时间：January 2011
• 年：2011
• 卷：34
• 期：1
• 页码：24-28
• 全文大小：101 K

Severe lower gastrointestinal (GI) bleeding is an infrequent complication in Crohn's disease.

We report the cases of three patients with Crohn's disease, localized in distinct areas, who developed severe enterorrhagia requiring multiple transfusions. All three patients responded favorably to infliximab administration, which resolved the life-threatening hemorrhages and avoided emergency surgical resection, which had seemed inevitable.

Based on this clinical experience and a review of the literature comparing infliximab with other pharmacological options, we believe that this drug should be the treatment of choice in patients with Crohn's disease who develop severe lower gastrointestinal bleeding. This strategy can, in some cases, avoid surgery if the bleeding stops due to rapid healing of the deep mucosal lesions causing the hemorrhagic episode.