The Cardiomyocyte RNA-Binding Proteome: Links to Intermediary Metabolism and Heart Disease
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- 作者：Yalin Liao1 ; Alfredo Castello2 ; 4 ; Bernd Fischer2 ; 5 ; Stefan Leicht2 ; Sophia Fö ; ehr2 ; Christian K. Frese2 ; Chikako Ragan1 ; Sebastian Kurscheid1 ; Eloisa Pagler1 ; Hao Yang1 ; Jeroen Krijgsveld2 ; 5 ; Matthias W. Hentze2 ; Thomas Preiss1 ; 3 ; thomas.preiss@anu.edu.au" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：2 August 2016
- 年：2016
- 卷：16
- 期：5
- 页码：1456-1469
- 全文大小：4148 K
文摘
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mRNA interactome capture and RBDmap reveal the cardiomyocyte RNA-binding proteome
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1,148 RBPs are identified, 393 of which are thus far unique to cardiomyocytes
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Many cardiac RBPs have links to heart disease and mitochondrial metabolism
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Contacts of metabolic enzymes with RNA frequently involve Rossmann fold domains