Alginate nanoparticles protect ferrous from oxidation: Potential iron delivery system
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- 作者：Nuwanthi P. Katuwavilaa ; c ; nanukanp@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; A.D.L.C. Pereraa ; b ; chandanip@pdn.ac.lk" class="auth_mail" title="E-mail the corresponding author ; Damayanthi Dahanayakec ; damayanthid@slintec.lk" class="auth_mail" title="E-mail the corresponding author ; V. Karunaratneb ; c ; veranjak@slintec.lk" class="auth_mail" title="E-mail the corresponding author ; Gehan A.J. Amaratungac ; d ; gehanA@slintec.lk" class="auth_mail" title="E-mail the corresponding author ; D. Nedra Karunaratnea ; b ; nedrak@pdn.ac.lk" class="auth_mail" title="E-mail the corresponding author ; nedrak37@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Sodium alginate (PubChem CID ; 5102882) ; Ferrous sulphate (PubChem CID ; 24393) ; Calcium chloride (PubChem CID ; 5284359) ; Sorbitanmonooleate (PubChem CID ; 9920342) ; l-Ascorbic acid (PubChemCID ; 54670067)
- 刊名：International Journal of Pharmaceutics
- 出版年：2016
- 出版时间：20 November 2016
- 年：2016
- 卷：513
- 期：1-2
- 页码：404-409
- 全文大小：1264 K
文摘
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A system with ability to protect iron in the reduced form.
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Alginate nanoparticles encapsulate ferrous ions.
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Delivery of iron from the system is pH dependant.
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Initial zero order kinetics for iron release are followed by slow release according to the Korsmeyer-Peppas model for drug release.
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Potential system for oral delivery of iron.