In vitro release of metformin hydrochloride from sodium alginate/polyvinyl alcohol hydrogels
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- 作者：Fabiá ; n Martí ; nez-Gó ; meza ; fabian.martinez@usach.cl" class="auth_mail" title="E-mail the corresponding author ; Juan Guerrerob ; Betty Matsuhiroa ; Jorge Pavezb
- 关键词：Sodium alginate ; Poly(vinyl alcohol) ; Hydrogel ; Metformin hydrochloride
- 刊名：Carbohydrate Polymers
- 出版年：2017
- 出版时间：2 January 2017
- 年：2017
- 卷：155
- 期：Complete
- 页码：182-191
- 全文大小：2998 K
文摘
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Sodium alginate (Mn 87.400 g/mol) (S. Alg) with definite composition was used.
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PH stimulus responsive S. Alg:PVA hydrogels were obtained by freeze-thaw cycles.
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1:1 w/v S.Alg/PVA hydrogels presented 20 g/g swelling ratio in distilled water.
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55% of metformin was released after 6 h at pH 8.0, from 1:1 w/v S.Alg/PVA hydrogel.