Sodium alginate and gum acacia hydrogels of ZnO nanoparticles show wound healing effect on fibroblast cells

详细信息    查看全文

• 作者：R. Raguvaran^a ; ^b ; Balvinder K. Manuja^a ; Meenu Chopra^a ; Rajesh Thakur^c ; Taruna Anand^a ; Anu Kalia^d ; Anju Manuja^a ; ^{amanuja@rediffmail.com}
• 关键词：Zinc oxide ; Nanoparticles ; Hydrogels ; Fibroblast cells ; Sodium alginate ; Gum acacia
• 刊名：International Journal of Biological Macromolecules
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：96
• 期：Complete
• 页码：185-191
• 全文大小：1949 K
• 卷排序：96

文摘

An ideal biomaterial for wound dressing applications should possess antibacterial and anti-inflammatory properties without any toxicity to the host cells while providing the maximum healing activity. Zinc oxide nanoparticles (ZnONPs) possess antimicrobial activity and enhance wound healing, but the questions regarding their safety arise before application to the biological systems. We synthesized ZnONPs-loaded-sodium alginate-gum acacia hydrogels (SAGA-ZnONPs) by cross linking hydroxyl groups of the polymers sodium alginate and gum acacia with the aldehyde group of gluteradehyde. Here, we report the wound healing properties of sodium alginate/gum acacia/ZnONPs, circumventing the toxicity of ZnONPs simultaneously. We demonstrated the concentration-dependent zones of inhibition in treated cultures of Pseudomonas aerigunosa and Bacillus cereus and biocompatability on peripheral blood mononuclear/fibroblast cells. SAGA-ZnONPs hydrogels showed a healing effect at a low concentration of ZnONPs using sheep fibroblast cells. Our findings suggest that high concentrations of ZnONPs were toxic to cells but SAGA-ZnONPs hydrogels significantly reduced the toxicity and preserved the beneficial antibacterial and healing effect.