Non-Cell-Autonomous Regulation of Prostate Epithelial Homeostasis by Androgen Receptor
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- 作者：Boyu Zhang1 ; Oh-Joon Kwon1 ; Gervaise Henry2 ; Alicia Malewska2 ; Xing Wei1 ; Li Zhang1 ; William Brinkley1 ; 3 ; Yiqun Zhang3 ; Patricia D. Castro4 ; Mark Titus5 ; Rui Chen6 ; Mohammad Sayeeduddin4 ; Ganesh V. Raj2 ; Ryan Mauck2 ; Claus Roehrborn2 ; Chad J. Creighton3 ; 7 ; Douglas W. Strand2 ; Michael M. Ittmann3 ; 4 ; 8 ; Li Xin1 ; 3 ; 4 ; 9 ; xin@bcm.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：androgen receptor ; epithelial homeostasis ; benign prostatic hyperplasia ; inflammation ; microenvironment ; macrophage ; interleukin-1
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：15 September 2016
- 年：2016
- 卷：63
- 期：6
- 页码：976-989
- 全文大小：6670 K
文摘
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AR expression is lower in luminal cells in inflamed human prostate tissues
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AR in luminal cells regulates epithelial barrier function and cytokine production
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Disrupting luminal AR signaling induces AR-independent epithelial proliferation
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IL-1 generated by macrophages regulates AR-independent epithelial proliferation