Spontaneous Pneumothorax in Wegener's Granulomatosis: Case Report and Literature Review

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• 作者：Moncef  ; Belhassen-Garcia MD^?/sup> ;   ; ^{mbelhassen@hotmail.com} ; Virginia  ; Velasco-Tirado MD^?/sup> ; Lucí ; a  ; Alvela-Suaré ; z MD^?/sup> ; Adela  ; Carpio-Pé ; rez MD ; PhD^?/sup> ; Javier Pardo  ; Lledí ; as MD ; PhD^&dagger ; ; Nuria  ; Novoa MD ; PhD^&dagger ; ; Alicia  ; Iglesias-Gó ; mez MD^&dagger ; ; Miguel  ; Cordero-Sá ; nchez MD ; PhD^&Dagger ;
• 关键词：spontaneous pneumothorax ; Wegener granulomatosis ; pyopneumotorax ; hydropneumothorax ; vasculitis
• 刊名：Seminars in Arthritis and Rheumatism
• 出版年：2011
• 出版时间：December 2011
• 年：2011
• 卷：41
• 期：3
• 页码：455-460
• 全文大小：708 K

文摘

Background

Pulmonary manifestations of Wegener's granulomatosis (WG) are present in 45 % of cases at the onset of the disease, and they reach 85 % of the patients during its evolution. Pulmonary affection usually starts with unspecific symptoms such as cough, dyspnea, hemoptysis, and pleuritis. Pulmonary nodules are 1 of the most common manifestations. The prevalence of pleural affection is 10 to 20 % . However, spontaneous pneumothorax is extremely rare. Although its real incidence is unknown, according to different classic series, it ranges between 3 and 5 % of the cases.

Objective

To present a new case of spontaneous pneumothorax in a patient suffering WG and a brief review on this subject.

Methods

We report our experience in a case of spontaneous pneumothorax due to WG. We also review the literature through a PubMed search between 1960 and 2010, using a broad range of keywords related to WG and spontaneous pneumothorax. Publications were evaluated for the demographic features of patients, manifestations of the disease, and outcome.

Results

Despite the large prevalence of the respiratory involvement, spontaneous pneumothorax is extremely rare, with only 21 cases reported in the literature.

Conclusion

Pneumothorax is a rare complication in WG cases, without a clear pathogenic mechanism involved.