Studies of antibacterial activity of binuclear rhodium(II) complexes with heterocyclic nitrogen ligands
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- 作者：Bien ; Malgorzata ; Pruchnik ; Florian P. ; Seniuk ; Alicja ; Lachowicz ; Tadeusz M. ; Jakimowicz ; Piotr
- 关键词：Rhodium(II) ; Antibacterial activity ; Binuclear rhodium(II) complexes ; Bipyridine complexes ; Phenanthroline complexes
- 刊名：Journal of Inorganic Biochemistry
- 出版年：1999
- 出版时间：January 2, 1999
- 年：1999
- 卷：73
- 期：1-2
- 页码：49-55
- 全文大小：482 K
文摘
Binuclear rhodium(II) complexes, [Rh2(OOCPh)2(phen)2(H2O)2](OOCPh)2 (1), [Rh2(OOCPh)2(bpy)2(H2O)2](OOCPh)2 (2), [Rh2(OOCBun)2(bpy)2(H2O)2](OOCBun)2 (3), and [Rh2(OOCPrn)2(phen)2(H2O)2](OOCPrn)2 (4) (phen = 1,10-phenanthroline and bpy = 2,2′-bipyridine), have been synthesized and characterized using NMR, IR and electronic spectra. Activity of these compounds against Gram-positive bacteria decreases in the order: 1?2?3?>4. Complex 1 is active against many Staphylococcus strains resistant to commonly used antibiotics. The complexes 1-4 are much less active agents against Gram-negative bacteria.