Regulation of invadopodia by mechanical signaling

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• 作者：Aron Parekh^a ; ^b ; ^{aron.parekh@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author} ; Alissa M. Weaver^b ; ^c ; ^d ; ^e ; ^{alissa.weaver@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Invadopodia ; Mechanotransduction ; Signaling ; Adhesion ; Contractility ; Actin ; Invasion ; Extracellular matrix ; Proteinases ; Secretion
• 刊名：Experimental Cell Research
• 出版年：2016
• 出版时间：10 April 2016
• 年：2016
• 卷：343
• 期：1
• 页码：89-95
• 全文大小：1078 K

文摘

Mechanical rigidity in the tumor microenvironment is associated with a high risk of tumor formation and aggressiveness. Adhesion-based signaling driven by a rigid microenvironment is thought to facilitate invasion and migration of cancer cells away from primary tumors. Proteolytic degradation of extracellular matrix (ECM) is a key component of this process and is mediated by subcellular actin-rich structures known as invadopodia. Both ECM rigidity and cellular traction stresses promote invadopodia formation and activity, suggesting a role for these structures in mechanosensing. The presence and activity of mechanosensitive adhesive and signaling components at invadopodia further indicates the potential for these structures to utilize myosin-dependent forces to probe and remodel their ECM environments. Here, we provide a brief review of the role of adhesion-based mechanical signaling in controlling invadopodia and invasive cancer behavior.