Reversal of the sleep-wake cycle by heroin self-administration in rats
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- 作者：Alissa A. Coffeya ; aac5186@psu.edu" class="auth_mail" title="E-mail the corresponding author ; Zhiwei Guanb ; zguan@hmc.psu.edu" class="auth_mail" title="E-mail the corresponding author ; Patricia S. Grigsona ; psg6@psu.edu" class="auth_mail" title="E-mail the corresponding author ; Jidong Fangb ; jfang@hmc.psu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Heroin ; Self-administration ; EEG ; EMG ; Sleep-wake ; Circadian rhythm
- 刊名：Brain Research Bulletin
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：123
- 期：Complete
- 页码：33-46
- 全文大小：3379 K
文摘
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Heroin self-administration during the light cycle reverses the rat sleep–wake cycle.
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Reversal does not depend on the amount of drug taken.
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Wake and NREM sleep patterns recover immediately in abstinence.
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REM sleep patterns remain reversed into early abstinence (3–6 days).