- 作者：Nicholas Matheson ; Robert A. Kingsley ; Katherine Sturgess ; Sani H. Aliyu ; John Wain ; Gordon Dougan ; Fiona J. Cooke
- 关键词：Salmonella enterica ; Enteric fever ; Typhoid fever ; Paratyphoid fever ; Gastroenteritis ; Epidemiology ; Fluoroquinolones ; Antibiotic resistance
- 刊名：Journal of Infection
- 出版年：2010
- 出版时间：January 2010
- 年：2010
- 卷：60
- 期：1
- 页码：21-25
- 全文大小：423 K
All Salmonella enterica isolated in the Clinical Microbiology Laboratory, Addenbrooke's Hospital between 1.1.1999 and 31.12.2008 were included. Patient demographics, serotype and additional relevant details (travel history, resistance-type, phage-type) were recorded.<h4 class=""h4"">Resultsh3>
1003 episodes of Salmonella gastroenteritis were confirmed by stool culture, representing 88 serotypes. Serotypes Enteritidis (59 % ), Typhimurium (4.7 % ), Virchow (2.6 % ), Newport (1.8 % ) and Braenderup (1.7 % ) were the 5 most common isolates. There were an additional 37 invasive Salmonella infections (32 blood cultures, 4 tissue samples, 1 CSF). 13/15 patients with Salmonella Typhi or Salmonella Paratyphi isolated from blood or faeces with an available travel history had returned from the Indian subcontinent. 8/10 S. Typhi or Paratyphi isolates tested had reduced susceptibility to fluoroquinolones (MIC ≥ 0.125 mg/L). 7/21 patients with non-typhoidal Salmonella bacteraemia were known to be immunosuppressed.<h4 class=""h4"">Conclusionh3>
This study describes Salmonella serotypes circulating within a defined geographical area over a decade. Prospective molecular analysis of isolates of S. enterica by multi-locus sequence typing (MLST) and single nucleotide polymorphism (SNP) detection will determine the geo-phylogenetic relationship of isolates within our region.