Alkali-earth metal bridges formed in biofilm matrices regulate the uptake of fluoroquinolone antibiotics and protect against bacterial apoptosis

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• 作者：Fuxing Kang^a ; Qian Wang^b ; Weijun Shou^a ; Chris D. Collins^c ; Yanzheng Gao^a ; ^{gaoyanzheng@njau.edu.cn} ; ^{gaosoil@163.com}
• 关键词：Fluoroquinolone antibiotics ; Biofilms ; Alkali&ndash ; earth metals ; Bridging energy ; Computational chemistry ; Escherichia coli
• 刊名：Environmental Pollution
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：220
• 期：part_PA
• 页码：112-123
• 全文大小：2604 K
• 卷排序：220

文摘

Weak interactions at the molecular level are quantitatively associated with a macroscopically biological effect. Metal bridge formed in extracellular biofilms acts through a suppressive trans-biofilm transport to protect bacterial cells. Bacterial growth rate depends on the bridging energy at the anchoring site.