A single polycystic kidney disease 2-like 1 channel opening acts as a spike generator in cerebrospinal fluid-contacting neurons of adult mouse brainstem
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- 作者：Adeline Orts-Del'Immaginea ; Riad Seddika ; Fabien Tellb ; Coraline Airaulta ; Ghizlane Er-Raouia ; c ; Mohamed Najimic ; Jé ; rô ; me Trouslarda ; Jerome.trouslard@univ-amu.fr" class="auth_mail" title="E-mail the corresponding author ; Nicolas Wanaverbecqa ; nicolas.wanaverbecq@univ-amu.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cerebrospinal fluid contacting neurons ; Sensory ; Alkalinization ; PKD2L1 ; ASIC ; AMPA ; Kainate ; nAChRs ; Brainstem
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：101
- 期：Complete
- 页码：549-565
- 全文大小：2287 K
文摘
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In vertebrates CSF contacting neurons (CSF-cNs) are found around the central canal.
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They selectively express a spontaneously active unitary current carried by PKD2L1.
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Extracellular acidification activates ASICs while alkalinization enhances PKD2L1 activity.
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PKD2L1 is capable at the level of a single channel of triggering action potential.
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Increased PKD2L1 activity directly enhances CSF contacting neurons excitability.