The regioselective bromine-lithium exchange reaction of alkoxymethyldibromobenzene: A new strategy for the synthesis of tofogliflozin as a SGLT2 inhibitor for the treatment of diabetes
Highly regioselective bromine-lithium exchange reaction of dibromobenzene derivative was realized. Dibromide as a starting material was found to be a mediator that increased the selectivity. Tofogliflozin was synthesized via three-component coupling.