Mutant allele specific imbalance in oncogenes with copy number alterations: Occurrence, mechanisms, and potential clinical implications
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- 作者：Chih-Chieh Yua ; Wanglong Qiua ; Caroline S. Juanga ; Mahesh M. Mansukhanib ; Balazs Halmosc ; Gloria H. Sua ; b ; d ; gs2157@columbia.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：MASI ; UPD ; Loss of wild-type allele ; KRAS ; EGFR ; PDAC
- 刊名：Cancer Letters
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：384
- 期：Complete
- 页码：86-93
- 全文大小：819 K
文摘
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This review describes and explains various classes of MASI pertaining to oncogenes and their significance in tumorigenesis.
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MASI at the EGFR and KRAS loci and their impacts on tumorigenesis and profound clinical implications are highlighted.
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The putative tumor-suppressive role of the wild-type KRAS allele in the context of the oncogenic KRAS allele is discussed.