Structure of the house dust mite allergen Der f 2: Implications for function and molecular basis of IgE cross-reactivity
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- 作者：Johannessen ; Birthe R. ; Skov ; Lars K. ; Kastrup ; Jette S. ; Kristensen ; Ole ; Bolwig ; Caroline ; et. al.
- 关键词：Eur m 2 ; Euroglyphus maynei major allergen 2 ; GM2-AP ; GM2-activator protein ; HE1 ; human epidymal secretory protein ; IgE ; immunoglobulin E ; Lep d 2 ; major type 2 allergen Lepidoglyphus destructor ; Der f 2 ; major type 2 allergen
- 刊名：FEBS Letters
- 出版年：2005
- 出版时间：February 14, 2005
- 年：2005
- 卷：579
- 期：5
- 页码：1208-1212
- 全文大小：399 K
文摘
The X-ray structure of the group 2 major allergen from Dermatophagoides farinae (Der f 2) was determined to 1.83 Å resolution. The overall Der f 2 structure comprises a single domain of immunoglobulin fold with two anti-parallel β-sheets. A large hydrophobic cavity is formed in the interior of Der f 2. Structural comparisons to distantly related proteins suggest a role in lipid binding. Immunoglobulin E (IgE) cross-reactivity between group 2 house dust mite major allergens can be explained by conserved surface areas representing IgE binding epitopes.