Direct versus sequential immunoglobulin switch in allergy and antiviral responses

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• 作者：E. Svirshchevskaya^a ; ^{esvir@mx.ibch.ru" class="auth_mail" title="E-mail the corresponding author} ; G. Fattakhova^a ; ^{fattakhova@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; S. Khlgatian^b ; ^{laball@yandex.ru" class="auth_mail" title="E-mail the corresponding author} ; D. Chudakov^a ; ^{boris-chudakov@yandex.ru" class="auth_mail" title="E-mail the corresponding author} ; E. Kashirina^a ; ^{helen-kas@mail.ru" class="auth_mail" title="E-mail the corresponding author} ; D. Ryazantsev^a ; ^{d.yu.ryazantsev@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; O. Kotsareva^a ; ^{olga.kotsareva@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; S. Zavriev^a ; ^{skz123@mail.ru" class="auth_mail" title="E-mail the corresponding author}
• 关键词：HDM ; house dust mites ; Der f ; Dermatophagoides farinae ; Der f 2 ; major allergen from D. farinae ; Alt a 1 ; major allergen from Alternaria alternata fungi ; pEBV ; polypeptide from EBNA-1 protein ; CSR ; class switch recombinations ; ILC2 ; innate lymphoid type 2 cells
• 刊名：Clinical Immunology
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：170
• 期：Complete
• 页码：31-38
• 全文大小：1004 K

文摘

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d="p0005">The onset of HDM or A. alternata allergy is manifested almost exclusively by the increase in specific IgE.

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d="p0010">These results are consistent with a direct mu to epsilon CSR in allergy.

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d="p0015">Antiviral response is characterized by IgG production with minor input of IgA and IgG4.

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d="p0020">Antiviral response is characterized by dominant direct mu to gamma switch.

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d="p0025">Sequential switches to IgA1, IgG4 and IgA2 do occur but represent rare events even in anti-EBV response.

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