Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival
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- 作者：Berna C. Ö ; zdemir1 ; 2 ; Tsvetelina Pentcheva-Hoang3 ; Julienne L. Carstens1 ; Xiaofeng Zheng1 ; Chia-Chin Wu4 ; Tyler R. Simpson3 ; Hanane Laklai5 ; Hikaru Sugimoto1 ; 2 ; Christoph Kahlert1 ; 2 ; Sergey V. Novitskiy6 ; Ana De Jesus-Acosta7 ; Padmanee Sharma3 ; Pedram Heidari8 ; Umar Mahmood8 ; Lynda Chin4 ; Harold L. Moses6 ; Valerie M. Weaver5 ; Anirban Maitra9 ; James P. Allison3 ; Valerie S. LeBleu1 ; 2 ; Raghu Kalluri1 ; 2 ; rkalluri@mdanderson.org" class="auth_mail
- 刊名：Cancer Cell
- 出版年：16 June 2014
- 年：2014
- 卷：25
- 期：6
- 页码：719-734
- 全文大小：7853 K
文摘
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Depletion of myofibroblasts in mouse pancreas cancer led to invasive tumors
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Decreases in fibrosis and myofibroblasts led to enhanced EMT and cancer stem cells
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Fewer myofibroblasts in tumors are associated with poor survival in mice and patients
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Immunotherapy combined with loss of myofibroblasts prolongs survival