Adoptive transfer of Aspergillus-specific T cells as a novel anti-fungal therapy for hematopoietic stem cell transplant recipients: Progress and challenges
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- 作者：Anastasia Papadopouloua ; b ; papada_1@hotmail.com" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Panayotis KaloyannidiscAuthor Vitae ; Evangelia Yannakia ; dAuthor Vitae ; Conrad Russell CruzeAuthor Vitae
- 关键词：Ag ; antigen ; allo-HSCT ; allogeneic hematopoietic stem cell transplantation ; APCs ; antigen presenting cells ; Asp ; Aspergillus ; Asp-STs ; Aspergillus-specific T cells ; CAR ; chimeric antigen receptor ; cGMP ; current good manufacturing practice ; CMV ; cytomegalovirus ; CSFs ; colony-stimulating factors ; D-CAR ; dectin-1 CAR ; DCs ; dendritic cells ; DC SIGN ; DC-specific ICAM3-grabbing non-integrin ; DLIs ; donor lymphocyte infusions ; EBV ; epstein-barr virus ; GvHD ; graft versus-host disease ; HSCT ; hematopoietic
- 刊名：Critical Reviews in Oncology and Hematology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：98
- 期：Complete
- 页码：62-72
- 全文大小：411 K
文摘
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We highlight advances in Asp-STs immunotherapy in the allogeneic transplant setting.
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We review evidence supporting a protective role of T cells against Aspergillus.
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We discuss critical issues on the development and protocol design of Asp-ST immunotherapy.