A promising sword of tomorrow: Human γδ T cell strategies reconcile allo-HSCT complications

详细信息    查看全文

• 作者：Yongxian Hu^a ; ¹ ; ^{huyongxian2000@aliyun.com" class="auth_mail" title="E-mail the corresponding author} ; Qu Cui^b ; ¹ ; ^{cncuiqu@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Chao Luo^c ; ^{68009172@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Yi Luo^a ; Jimin Shi^a ; He Huang^a ; ^{hehuang.zju@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Allogeneic hematopoietic stem cell transplantation ; γδ T cells ; Leukemia ; Relapse ; Graft versus host disease ; Infection
• 刊名：Blood Reviews
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：30
• 期：3
• 页码：179-188
• 全文大小：905 K

文摘

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is potentially a curative therapeutic option for hematological malignancies. In clinical practice, transplantation associated complications greatly affected the final therapeutical outcomes. Currently, primary disease relapse, graft-versus-host disease (GVHD) and infections remain the three leading causes of a high morbidity and mortality in allo-HSCT patients. Various strategies have been investigated in the past several decades including human γδ T cell-based therapeutical regimens. In different microenvironments, human γδ T cells assume features reminiscent of classical Th1, Th2, Th17, NKT and regulatory T cells, showing diverse biological functions. The cytotoxic γδ T cells could be utilized to target relapsed malignancies, and recently regulatory γδ T cells are defined as a novel implement for GVHD management. In addition, human γδ Τ cells facilitate control of post-transplantation infections and participate in tissue regeneration and wound healing processes. These features potentiate γδ T cells a versatile therapeutical agent to target transplantation associated complications. This review focuses on insights of applicable potentials of human γδ T cells reconciling complications associated with allo-HSCT. We believe an improved understanding of pertinent γδ T cell functions would be further exploited in the design of innovative immunotherapeutic approaches in allo-HSCT, to reduce mortality and morbidity, as well as improve quality of life for patients after transplantation.