The effect of introducing small cavities on the allosteric inhibition of phosphofructokinase from Bacillus stearothermophilus
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- 作者：Amy M. Whitaker1 ; Gregory D. Reinhart ; gdr@tamu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Allosterism ; Cavities
- 刊名：Archives of Biochemistry and Biophysics
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：607
- 期：Complete
- 页码：1-6
- 全文大小：735 K
文摘
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Ile → val introduces small cavities into PFK from Bacillus stearothermophilus.
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Small cavities influence allosteric behavior without appreciably affecting catalysis.
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Small cavities have a bigger effect on the allosteric coupling ΔH and TΔS than on ΔG.
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Small cavities can enhance or diminish the inhibition by PEP depending on location.