Inhibitory effects of S-allylmercaptocysteine against benzo(a)pyrene-induced precancerous carcinogenesis in human lung cells
详细信息 查看全文
- 作者：Kaiming Wanga ; Ying Wanga ; Qiuchen Qia ; Fang Zhanga ; Yongchun Zhanga ; b ; Xiaosong Zhua ; Guangpu Liua ; Yuxia Luana ; Zhongxi Zhaoa ; c ; zxzhao@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Jianhua Caic ; Jimin Caoc ; Shanzhong Lic
- 关键词：Benzo(a)pyrene ; S-allylmercaptocysteine ; Cancer therapy ; A549 ; ROS ; NF-κB
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：34
- 期：Complete
- 页码：37-43
- 全文大小：887 K
文摘
- •
SAMC inhibits B(a)P-induced cell proliferation and cell cycle changes.
- •
SAMC attenuates production of ROS in B(a)P-activated A549 cells.
- •
SAMC inhibits decrease of SOD activities.
- •
SAMC exhibits these effects by suppression of NF-κB pathways.